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ScienCell
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Image Search Results
Journal: Molecular Pharmacology
Article Title: A Dietary Agonist of Transient Receptor Potential Cation Channel V3
Elicits Endothelium-Dependent Vasodilation
doi: 10.1124/mol.109.060715
Figure Lengend Snippet: Carvacrol stimulates TRPV3 cation currents in cerebral artery endothelial cells A, representative whole-cell currents recorded from human microvascular cerebral artery endothelial cells during voltage ramps from −100 to +100 mV. Current density is shown for cells under baseline conditions (B) and after first (1), second (2), and third (3) application of carvacrol (100 μM). B, summary data demonstrating sensitization of the carvacrol-induced current (n = 6). C, summary data showing the effects of the TRPA1 antagonist HC-030031 (HC, 3 μM) and the TRPV1–4 blocker RuR (10 μM) on carvacrol-induced currents recorded from cerebral artery endothelial cells; n = 5 for HC-030031, n = 4 for ruthenium red. Current magnitude was normalized to peak carvacrol-induced currents. *, P ≤ 0.05 versus control (C).
Article Snippet: Carvacrol-activated currents were recorded from human
Techniques: Control